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pentobarbital will decrease the level or outcome of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.pentobarbital will minimize the extent or impact of fentanyl by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Coadministration of fentanyl with CYP3A4 inducers

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